Because most cases of sinusitis are caused by bacterial or viral infection, such infections should be treated aggressively—at the first sign of infection—to prevent them from spreading into the sinuses. In addition to getting plenty of rest and drinking a lot of fluid, sufferers may take the following supplements, which have been shown to inhibit infection with viral or bacterial agents that cause the common cold and influenza:
Dehydroepiandrosterone (DHEA). Aging humans gradually lose youthful levels of DHEA, an adrenal hormone and precursor to other important hormones in the body (Shealy CN 1995). Numerous studies have shown that DHEA causes powerful immune-enhancing and antiviral effects (Ben-Yehuda A et al 1998; Corsini E et al 2002; Danenberg HD et al 1995, 1997; Degelau J et al 1997; Padgett DA et al 1997, 2000). The administration of 50 mg DHEA daily to older men resulted in the following immune enhancements compared to placebo :
35 percent increase in the number of monocyte immune cells
29 percent increase in the number of B immune cells
62 percent increase in B cell activity
40 percent increase in T cell activity
50 percent increase in interleukin (IL)-2
22 percent to 37 percent increase in natural killer (NK) cell number
45 percent increase in NK cell activity
One reason influenza can be so lethal to older people is that their immune systems are weak. A deficiency in DHEA appears to be partially responsible for the age-related decline in immune function (Fulop T Jr et al 1999; Khorram O et al 1997). One study showed that a metabolite of DHEA augmented activation of helper T cells and protected mice from a lethal influenza virus infection (Padgett DA et al 1997).
Lactoferrin. Lactoferrin has well-documented antiviral, antimicrobial, anticancer, and immune enhancing effects. Lactoferrin secretion is increased during sinusitis, leading researchers to conclude that it is a potent part of the body’s natural defense mechanism against sinusitis.
Lactoferrin has been found to directly and indirectly inhibit viruses such as respiratory syncytial virus, human HIV, cytomegalovirus, and herpes simplex type I infection (Puddu P et al 1998; Superti F et al 1997; Harmsen MC et al 1995; Swart PJ et al 1996, 1998; Sano H et al 2003). Specifically, lactoferrin has been shown to increase NK cells (Yamauchi K et al 1998; Swart PJ et al 1998; Waarts BL et al 2005).
Lactoferrin may stimulate macrophages, which in turn may help to induce cell-mediated immunity. Although many of the studies of lactoferrin’s functioning have involved animals, lactoferrin is naturally present in many mucous membrane secretions in people, suggesting an innate human antimicrobial function (Nishiya K et al 1982; Zimecki M et al 2002).
A recent study showed that human lactoferrin interferes with the ability of certain viruses to bind to cell receptor sites (Waarts BL et al 2005).
Melatonin. Melatonin, a hormone produced by the pineal gland, has immunity-enhancing benefits in addition to its well-known role as a sleep aid. Melatonin enhances the production of key immune system components, such as NK cells, IL-2, IL-4, IL-10, and gamma interferon (Lissoni P et al 1989, 1994, 1995; Maestroni GJ 1999; Bubenik GA et al 1998). Melatonin has been specifically shown to decrease viral load and prevent death in mice infected with certain viruses. One study of melatonin concluded, “The immunomodulatory, antioxidant, and neuroprotective effects of melatonin suggest that this indole must be considered as an additional therapeutic alternative to fight viral diseases” (Maestroni GJ 1999).
Another study reviewed animal research that examined the immune function benefits of melatonin and found that melatonin activated IL-2 and gamma interferon, the body’s natural hormone-like agents that facilitate helper T cell production (Bonilla E et al 2004).
Garlic. With all the high-tech advances occurring in medicine, garlic might be expected to be a relic of the past. Yet the scientific literature documents that garlic has powerful effects against certain viruses.
For instance, one study tested one capsule daily of an allicin-containing garlic supplement (like Pure Gar) on a group of 146 volunteers (Josling P 2001). Over several months half the group received the garlic while the other half got a placebo. The placebo group had 63 percent more common cold infections than the garlic group. Even more significant, those in the garlic group who did catch a cold had symptoms for an average of only 1.52 days, compared with 5.01 days for the placebo group. The doctors who conducted this garlic study concluded, “An allicin-containing supplement can prevent attack by the common cold virus.”
Ribavirin is a prescription drug that has potent antiviral effects (Cattral MS et al 1996; Christie JM et al 1999; da Silva LC et al 2002; de Ledinghen V et al 2002; Di Bisceglie AM et al 1995; Fried MW et al 2002; Galban GE et al 2000; Kumada H 2002; Murphy ME et al 2000; Reichard O et al 1998; Schalm SW et al 1997a,b,1999; Schvarcz R et al 1995). Yet, a Chinese study has found that (at least in the test tube) garlic is more effective than ribavirin in inhibiting viruses that attack the intestinal tract (Luo R et al 2001). Since 1983 the Life Extension Foundation has recommended ribavirin to treat various viral infections, but in this particular study, garlic was shown to be superior.
A number of published studies indicate that both high-allicin garlic (such as Pure Gar) and aged garlic (such as Kyolic aged garlic) support healthy immune function while exerting antiviral effects (Guo NL et al 1993; Josling P 2001; Kyo E et al 2001; Liu ZF et al 2004; Moon DG et al 2000; Tsai Y et al 1985; Weber ND et al 1992). Garlic may be nature’s most powerful weapon against certain viruses.
Essential fatty acids. Maintaining the proper ratio of omega-3 to omega-6 fatty acids can maximize the production of anti-inflammatory prostaglandins E1 and E3 while suppressing proinflammatory prostaglandin E2 and leukotriene B4. Most people consume too much omega-6 relative to omega-3 fatty acids. The main omega-3 fatty acids are docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA and EPA exert anti-inflammatory and antithrombotic effects, partly by competing with pro-inflammatory chemicals (Calder PC 2005; Conner WE 2001). Studies suggest that fish oils reduce the production of pro-inflammatory cytokines such as interleukin-1 beta and tumor necrosis factor. Additionally, they can suppress B- and T-lymphocyte synthesis (Kelley DS et al 2000; Endres S et al 1993; Burns EA et al 2004).
Green tea. Green tea, which is rich in antioxidants, has demonstrated the ability to inhibit bacteria (Sakanaka S et al 2000; Stapleton PD et al 2004) and viruses (Song JM et al 2005) and has also been shown to have a protective effect on immune function (Yamamoto Y et al 2004).
Vitamin C. Vitamin C is a potent free radical scavenger and antioxidant derived from citrus fruits and green vegetables. It protects tissues from oxidative stress and enables the actions of vitamin E. Vitamin C in high doses may reduce symptoms associated with viruses and respiratory infections such as colds and flu, which are associated with sinusitis (Gorton HC et al 1999; Hemila H 2004). Multiple studies have found that high doses of vitamin C alleviate common cold and flu symptoms, indicating that the vitamin does indeed have physiologic effects on colds (Hemila H 1997, 2004; Gorton HC et al 1999). In a five-year clinical trial of 50 mg versus 500 mg vitamin C daily, the high-dose group reported fewer colds than the low-dose group (Sasazuki S et al 2005). From a meta-analysis of four double-blind, placebo-controlled trials, Linus Pauling found a 45 percent decrease in the incidence of colds when 1000 mg ascorbic acid (vitamin C) was used daily (Pauling L 1971). Some studies, however, show that vitamin C does not affect the frequency or duration of a common cold.
Zinc. Zinc supports the actions of antiseptic agents and kills microbes directly (Zeelie JJ et al 1998; Sheng J et al 2005). Zinc deficiency is closely associated with susceptibility to infection (Bogden 2004). A number of published studies show that, if zinc lozenges are taken within 24 hours of the onset of common cold symptoms, the severity and duration of cold miseries are significantly diminished (Hulisz D 2004; Prasad AS et al 2000; Marshall S 1998; Mossad SB et al 1996).
Rhinoviruses attach to specific cell receptor sites in sinus and throat tissues, become lodged in the nose and throat, and then replicate out of control. By binding to the same cell receptor sites as do cold viruses, zinc inhibits the ability of rhinoviruses to take hold in the body (Gwaltney JM 2002).
A meta-analysis of all the published literature on zinc lozenges was conducted in 2004 and concluded, “Clinical trial data support the value of zinc in reducing the duration and severity of symptoms of the common cold when administered within 24 hours of the onset of common cold symptoms. Additional clinical and laboratory evaluations are warranted to further define the role of ionic zinc for the prevention and treatment of the common cold and to elucidate the biochemical mechanisms through which zinc exerts its symptom-relieving effects” (Hulisz D 2004).
Patients seeking to relieve cold symptoms by means of zinc should suck on two 24-mg zinc lozenges at the very first symptom of a cold and take two more lozenges every two hours while awake. Once rhinoviruses bind to their receptor sites in the nasal tissues and begin replicating, zinc lozenges lose their efficacy. Considering how inexpensive zinc lozenges are, it makes sense to keep them on hand so that they are available immediately if cold symptoms appear.
One caveat is that chronic use of zinc in doses of more than 100 mg daily may suppress immune function (Chandra RK 1984). If someone takes two zinc lozenges every two hours over the course of a day, the total zinc intake could easily exceed 300 mg daily. This does not appear to be a problem in the short term. If your cold symptoms do not subside after a few days of taking zinc lozenges, it would be best to stop taking them. Remember that less than 100 mg zinc daily can improve immune function, but taking more than 100 mg daily concerns some doctors. For more Information
The Immune Enhancement Chapter may be of additional interest.
Propolis. Before the discovery of antibiotics, honey was used in the fight against bacteria. The antibacterial effects of this folk remedy have since been confirmed by scientific study ( Lusby PE et al 2005). In addition, in vitro and in vivo studies have shown that bee propolis has antiviral and anti-inflammatory properties and an inhibitory effect on the growth and adherence of streptococci bacteria (Cohen HA et al 2004; Duarte S et al 2003; Mirzoeva OK et al 1996; Serkedjieva J et al 1992; Szmeja Z et al 1989). One study demonstrated that propolis decreased the duration of the common cold to just a few days. This study showed that cold symptoms in the propolis treatment group improved 2.5 times faster than in the placebo group (Szmeja Z et al 1989).
Warning: Raw honey should NEVER be given to a child under one year of age because it presents a significant risk of potentially fatal botulism. This risk vanishes in older children and adults.
Beta-carotene and vitamin E. Beta-carotene has been shown to have a powerful effect in boosting NK cell activity in older men. In a controlled, double-blind study, the effects of 10 to 12 years of beta-carotene supplementation on NK cell activity were evaluated. Although no significant difference was seen in NK cell activity in the middle-aged groups, older men supplemented with beta-carotene had significantly greater NK cell activity than the control group of men of comparable age (Santos et al 1996).
The best-publicized study of the use of vitamin E to boost immune function appeared in 1997 (Meydani et al 1997). The double-blind, placebo-controlled study looked at healthy humans at least 65 years of age. Supplementation with vitamin E for four months improved certain clinically relevant indices of cell-mediated immunity. These results show that a level of vitamin greater than that currently recommended by the Food and Drug Administration enhances certain clinically relevant in vivo indices of T-cell-mediated immune function in healthy older persons.
N-acetylcysteine. N-acetylcysteine (NAC) is an acetylated ester of the amino acid L-cysteine. NAC raises levels of glutathione, a potent internal antioxidant (Roes EM et al 2002). For many years, NAC has been used to treat bronchitis and other lung conditions as an expectorant or mucus thinner as well as an anti-inflammatory.
Rosmarinic acid. Rosmarinic acid is a plant polyphenol found in plants of the Lamiaceae genus, which includes basil, sage, mint, rosemary, and perilla leaf (al Sereiti MR et al 1999). Oral supplementation with extracts of rosmarinic acid has been shown to suppress allergic reactions in mice and, more recently, in humans (Makino T et al 2001; Takano H et al 2004). Rosmarinic acid relieves allergy symptoms by preventing the activation of immune responder cells and by inducing apoptosis, or cellular suicide, in already activated immune responder cells (Hur YG et al 2004). Natural flavonoids like rosmarinic acid kill only excess allergy-activated immune cells while leaving the vast bulk of responder cells to fight off bacteria and other foreign invaders, thus possibly preventing the progression to allergic sinusitis. Life Extension Foundation Recommendations
People with sinusitis often benefit from steam treatments and nasal saline wash. In addition, the following supplements are suggested to prevent infection:
DHEA —15 to 75 milligrams (mg) for three to six weeks, followed by blood testing to make sure optimal levels of this hormone are maintained. If symptoms of an infection are just beginning, 200 to 400 mg may be taken as soon as possible.
Lactoferrin —900 mg daily with meals, or 1200 mg at the first sign of infection
Melatonin —3 to 10 mg prior to bedtime, or up to 50 mg at the first sign of infection
Pure Gar garlic —9000 mg once or twice daily (eat other food immediately after ingesting the garlic to minimize stomach or esophageal burning.)
Kyolic aged garlic extract—3600 mg daily
Essential fatty acids —700 to 1400 mg of EPA and 500 to 1000 mg of DHA daily with food
Zinc—Suck on two 24-mg lozenges every two hours while awake, beginning at the first sign of symptoms. This should be continued for only a few days to avoid toxic side effects. Continue with 30 mg of orally ingested zinc daily.
Beta-carotene— 25,000 international units (IU) daily
Vitamin C—2.5 to 6 grams (g) daily
Vitamin E —400 IU of alpha-tocopherol and 200 mg or more of gamma-tocopherol daily
NAC— 600 mg twice daily with vitamin C
Propolis —500 to 1500 mg daily
Green tea —725 mg green tea powder extract. Use a decaffeinated formula if you are sensitive to caffeine.
Rosmarinic acid—100 mg daily
Sinusitis Safety Caveats
An aggressive program of dietary supplementation should not be launched without the supervision of a qualified physician. Several of the nutrients suggested in this protocol may have adverse effects. These include:
Do not take beta-carotene if you smoke. Daily intake of 20 milligrams or more has been associated with a higher incidence of lung cancer in smokers.
Taking 30 milligrams or more daily for prolonged periods can cause carotenoderma, a yellowish skin discoloration (carotenoderma can be distinguished from jaundice because the whites of the eyes are not discolored in carotenoderma).
Do not take DHEA if you could be pregnant, are breastfeeding, or could have prostate, breast, uterine, or ovarian cancer.
DHEA can cause androgenic effects in woman such as acne, deepening of the voice, facial hair growth and hair loss.
Consult your doctor before taking EPA/DHA if you take warfarin (Coumadin). Taking EPA/DHA with warfarin may increase the risk of bleeding.
Discontinue using EPA/DHA 2 weeks before any surgical procedure.
Garlic has blood-thinning, anticlotting properties.
Discontinue using garlic before any surgical procedure.
Garlic can cause headache, muscle pain, fatigue, vertigo, watery eyes, asthma, and gastrointestinal symptoms such as nausea and diarrhea.
Ingesting large amounts of garlic can cause bad breath and body odor.
Consult your doctor before taking green tea extract if you take aspirin or warfarin (Coumadin). Taking green tea extract and aspirin or warfarin can increase the risk of bleeding.
Discontinue using green tea extract 2 weeks before any surgical procedure. Green tea extract may decrease platelet aggregation.
Green tea extract contains caffeine, which may produce a variety of symptoms including restlessness, nausea, headache, muscle tension, sleep disturbances, and rapid heartbeat.
Do not take melatonin if you are depressed.
Do not take high doses of melatonin if you are trying to conceive. High doses of melatonin have been shown to inhibit ovulation.
Melatonin can cause morning grogginess, a feeling of having a hangover or a “heavy head,” or gastrointestinal symptoms such as nausea and diarrhea.
NAC clearance is reduced in people who have chronic liver disease.
Do not take NAC if you have a history of kidney stones (particularly cystine stones).
NAC can produce a false-positive result in the nitroprusside test for ketone bodies used to detect diabetes.
Consult your doctor before taking NAC if you have a history of peptic ulcer disease. Mucolytic agents may disrupt the gastric mucosal barrier.
NAC can cause headache (especially when used along with nitrates) and gastrointestinal symptoms such as nausea and diarrhea.
Propolis, when ingested, can cause hypersensitivity reactions such as rhinitis, conjunctivitis, rash, and bronchospasm.
Do not take vitamin C if you have a history of kidney stones or of kidney insufficiency (defined as having a serum creatine level greater than 2 milligrams per deciliter and/or a creatinine clearance less than 30 milliliters per minute.
Consult your doctor before taking large amounts of vitamin C if you have hemochromatosis, thalassemia, sideroblastic anemia, sickle cell anemia, or erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency. You can experience iron overload if you have one of these conditions and use large amounts of vitamin C.
Consult your doctor before taking vitamin E if you take warfarin (Coumadin).
Consult your doctor before taking high doses of vitamin E if you have a vitamin K deficiency or a history of liver failure.
Consult your doctor before taking vitamin E if you have a history of any bleeding disorder such as peptic ulcers, hemorrhagic stroke, or hemophilia.
Discontinue using vitamin E 1 month before any surgical procedure.
For more information see the Safety Appendix
Chemistry Panel & Complete Blood Count (CBC) Blood Test
C-Reactive Protein (CRP), Cardiac Blood Test
Allergen Profile, Mini-panel Blood Test
Allergen Profile, Mold Blood Test
Allergen Profile, Fall Blood Test
DHEA (Dehydroepiandrosterone), 15 mg 100 capsules
DHEA (Dehydroepiandrosterone), 25 mg 100 capsules
DHEA, 50 mg 60 capsules
Melatonin, 3 mg 60 capsules
Melatonin 6 Hour Timed Release, 3 mg 60 capsules
Vitamins & Supplements
CoQ10 (Coenzyme Q10)
Fish Oil (Omega-3)
PQQ (Pyrroloquinoline Quinone)